![]() ![]() The cookie is used to store the user consent for the cookies in the category "Analytics". This cookie is set by GDPR Cookie Consent plugin. These cookies ensure basic functionalities and security features of the website, anonymously. Hepatic impairment, pregnancy (during 2 nd & 3 rd trimesters), nursing mothers: not recommended.Necessary cookies are absolutely essential for the website to function properly. Measure hematologic parameters annually and Vit. Discontinue if hypersensitivity reaction occurs treat promptly and monitor until resolve. Increased risk of genital mycotic infections, UTIs (including urosepsis, pyelonephritis) monitor and treat as appropriate. Necrotizing fasciitis of the perineum (Fournier's gangrene) discontinue and treat immediately if suspected use alternative antidiabetic. Consider temporarily discontinuing prior to scheduled surgery (for ≥3 days) or other clinical situations (eg, prolonged fasting due to illness or post-surgery). Assess for ketoacidosis in presence of signs/symptoms of metabolic acidosis, regardless of blood glucose levels discontinue if suspected, evaluate and treat consider risk factors before initiation (eg, pancreatic insulin deficiency, caloric restriction, alcohol abuse). Assess volume status and renal function prior to initiation monitor during therapy more frequently in elderly. Increased risk for volume depletion or hypotension in those with renal impairment (eGFR <60mL/min/1.73m 2), elderly, or on loop diuretics. Correct volume depletion before initiating. Discontinue at time of, or prior to intravascular iodinated contrast imaging in patients with eGFR <60mL/min/1.73m 2, history of hepatic impairment, alcoholism, heart failure, or will be given intra-arterial contrast reevaluate eGFR 48hrs after procedure and restart therapy if renally stable. Increased risk of metformin-associated lactic acidosis in renal or hepatic impairment, concomitant use of certain drugs (eg, cationic drugs), ≥65yrs of age, undergoing radiological contrast study, surgery and other procedures, hypoxic states, and excessive alcohol intake discontinue if lactic acidosis is suspected. ![]()
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